Sbelia Professional: The Science of Skin Firming and Body Contouring

A Comprehensive Clinical Solution for Aesthetic Medicine

For over 25 years, Praxis sterile ampoules have been the professional’s choice in aesthetic medicine clinics across the globe. Sbelia, our advanced reducing and firming solution, represents the culmination of decades of clinical expertise and scientific research. This professional-grade formula is designed specifically for use in aesthetic treatments, offering evidence-based support for body contouring, flaccidity improvement, and skin revitalization.

Clinical Foundations: The Science of Transdermal Delivery

Understanding the science of transdermal penetration is essential to appreciating how Sbelia achieves its clinical results. Skin permeation occurs primarily through two distinct pathways, each with its own significance in aesthetic medicine.

The Two Penetration Routes

1. Transappendageal Route (Shunt Pathway)

This pathway involves transport through skin appendages—specifically, hair follicles, sebaceous glands, and sweat glands . Research demonstrates that the transappendageal route provides a significant contribution to percutaneous absorption, with studies showing that active ingredients can penetrate more rapidly through these structures than through intact stratum corneum . This “shunt” diffusion is particularly valuable in aesthetic medicine, as it enables more rapid delivery of active compounds to the dermal layers where they can exert their effects . Clinical investigations have confirmed that skin appendages contribute substantially to the penetration of both lipophilic and hydrophilic molecules .

2. Transepidermal Route

The transepidermal pathway involves transport through the intact stratum corneum. This can occur via the intercellular route—through the lipid matrix surrounding corneocytes—or via the transcellular route, which moves directly through corneocytes and their intervening lipids . The intercellular route is particularly significant for lipid-soluble compounds . In practice, achieving optimal results with transdermal delivery systems often involves utilizing both pathways to maximize active ingredient penetration .

Clinical Application Advantage

Sbelia is designed for professional application techniques including virtual mesotherapy, dermapen, and dermaroller. These advanced delivery methods enhance both the transappendageal and transepidermal routes, accelerating penetration depth and improving clinical outcomes . When combined with these techniques, Sbelia’s isotonic formulation provides exceptional skin tolerance while delivering active botanical extracts where they are needed most.

Product Composition: A Synergistic Botanical Complex

Sbelia’s formula combines high-quality plant extracts in an aqueous, isotonic sodium chloride vehicle—a formulation approach that ensures both efficacy and skin tolerance. The active botanical complex includes :

Complete composition: Aqua, Sodium Chloride (isotonic concentration), plant extracts (Fucus vesiculosus, Equisetum arvense, Alchemilla vulgaris, Solidago Virgaurea, Betula alba), Alcohol .

The Isotonic Advantage

Sbelia’s formulation uses sodium chloride in isotonic concentration, a critical feature that provides high tolerance across all skin types . This isotonic environment minimizes tissue irritation while creating optimal conditions for active ingredient delivery. The water-soluble, non-oily base ensures compatibility with other aesthetic treatments and eliminates concerns about pore occlusion or incompatibility with professional protocols.

Clinical Evidence for Key Components

The ingredients in Sbelia are supported by clinical research demonstrating their efficacy in improving skin quality and reducing signs of aging.

Coenzyme Q10 (CoQ10)

Clinical studies examining CoQ10 supplementation have demonstrated significant anti-aging benefits. In a 12-week clinical investigation, subjects receiving CoQ10 showed improvements in skin smoothness (70-82% of subjects, depending on dosage), microrelief (60-64% improvement), and skin firmness (70% improvement at higher doses) . Viscoelasticity measurements showed dose-dependent improvements significantly different from placebo, confirming CoQ10’s role in maintaining skin mechanical properties .

Collagen and Associated Ingredients

A comprehensive observational study evaluating dietary supplementation with collagen, chondroitin sulfate, low-molecular weight hyaluronic acid, Pycnogenol®, and coenzyme Q10 found significant improvements in age-related dermatological changes. At 12 weeks, participants showed significant improvements (p < 0.01 to p < 0.001) in skin hydration, Trans Epidermal Water Loss (TEWL), and skin elasticity across multiple facial areas . These findings support the role of combined collagen-based formulations in improving skin quality parameters relevant to flaccidity and aging concerns.

Ginkgo Biloba

Ginkgo biloba contains bioactive compounds including flavonoids, terpene triflactones, and proanthocyanidins. Research has documented Ginkgo’s photoprotective effects and its potential to inhibit matrix metalloproteinases (MMPs), including collagenase, which degrades dermal matrix proteins . This anti-collagenase activity is particularly relevant for maintaining skin firmness and preventing age-related dermal matrix degradation . Clinical studies have further examined Ginkgo’s role in combination formulations, demonstrating efficacy in improving wrinkle parameters and skin elasticity .

Clinical Applications

Sbelia is indicated for professional use in a variety of aesthetic treatments :

• Body Contouring: Fat reduction, cellulite improvement, skin flaccidity

• Skin Rejuvenation: Facial aging, comprehensive skin revitalization

• Stretch Marks: Improvement of skin texture and appearance

• Acne-Prone Skin: Support for skin health and recovery

• Additional Benefits: Lymphatic and vascular drainage, pain management, sports recovery support

A Trusted Choice: 25 Years of Excellence

Our sterile ampoule line has been utilized in aesthetic and cosmetic medicine clinics for over 25 years, a testament to the trust clinicians place in Praxis formulations . The quality standards our active ingredients meet include :

• Water solubility for optimal delivery

• Isotonicity for skin tolerance

• Integration of natural active ingredients

• Synergistic effects between components

• Absence of intolerances and side effects

• No oily components for non-comedogenic use

• Full compatibility with other treatment protocols

Quality and Safety

Sbelia ampoules are sterile and intended for professional use only. The product is not for injection, reflecting our commitment to the safe and effective application of active ingredients through appropriate aesthetic medicine protocols. The CPNP registration (2557786) confirms compliance with European cosmetic product notification requirements.

Bibliography

1. MIPMED. Ampolas de Mesoterapia Praxis – Sbelia – Solução Redutora e Reafirmante. Disponível em: https://mipmed.com/mesotherapy-aesthetics/mesotherapy-ampoules-reducing-and-firming-solution

2. Clinical, Cosmetic and Investigational Dermatology. 2015;8:389–396. https://www.dovepress.com/article/download/22642

3. Percutaneous Absorption Routes. In: Pharmaceutical Sciences Encyclopedia. https://prr.hec.gov.pk/jspui/bitstream/123456789/1408/2/1197S.pdf

4. ECOIRIS. Sbelia – Solução Redutora e Firmadora. https://ecoiris.pt/pt/cosmeticos/1163-sbelia-solucao-redutora-e-firmadora-5608780555182.html

5. Examine.com. Wrinkles: How diet, lifestyle, and supplements may provide benefits. 2024. https://examine.com/outcomes/wrinkles/

6. Nature Communications. The transdermal mechanism of FCS-containing nanocomplexes. 2024. https://www.nature.com/articles/s41467-024-45158-6/figures/2

7. Skin Pharmacology and Physiology. Coenzyme Q10 Supplementation and Skin Aging. Slovenian Research Agency. https://dirros.openscience.si/Dokument.php?id=36339

8. Hueber F, et al. Role of transepidermal and transfollicular routes in percutaneous absorption of hydrocortisone and testosterone: in vivo study in the hairless rat. Skin Pharmacol. 1992. https://pubmed.ncbi.nlm.nih.gov/1637565/

9. Laurino C, Palmieri B, Coacci A, Vadala M. A dietary supplement improves age-related dermatological changes. Observational, anecdotal, spontaneous study. Asian Journal of Medical Sciences. 2017;8(3):16-25. https://ajmsjournal.info/index.php/AJMS/article/view/2732

10. Jadoul A, Hanchard C, Thysman S, Préat V. Quantification and localization of fentanyl and TRH delivered by iontophoresis in the skin. International Journal of Pharmaceutics. 1995;120:221-228. 

11. Illel B, et al. Transfollicular percutaneous absorption. Skin model for quantitative studies. Acta Derm Venereol. 1988. https://pubmed.ncbi.nlm.nih.gov/2461027/

12. Kao J, Hall J, Helman G. In vitro percutaneous absorption in mouse skin: Influence of skin appendages. Toxicology and Applied Pharmacology. 1988;94(1):93-103. 

13. ScienceDirect. Skin Permeability. In: Nanoscience in Dermatology. 2016. https://www.sciencedirect.com/topics/immunology-and-microbiology/skin-permeability

For professional use only. This information is intended for healthcare professionals and aesthetic medicine practitioners.

CPNP: 2557786